Department: Biology
Job Title: Senior Scientist, Translational Research (AP24534)
Description:
We are seeking a Ph.D.-level scientist to lead translational studies to support development of AP24534, our multi-targeted kinase inhibitor, as it begins clinical testing. This scientist will perform research to understand the activity of AP24534 as a third-generation Bcr-Abl inhibitor, and to define additional potential therapeutic applications based on its promising activity against a panel of oncogenic and angiogenic kinases implicated in a variety of malignancies.
Responsibilities:
- Oversee pharmacodynamic and biomarker studies that will be conducted in initial Phase 1 clinical trials.
- Conduct cutting-edge research aimed at identifying promising biomarkers of drug activity in a variety of tumor types.
- Identify and collaborate with external investigators with relevant expertise.
- Translate the results of preclinical studies into clinical studies aimed at defining drug activity in new indications.
- Generate study reports and present study results.
- Interact closely with heads of the Translational Research, Clinical and Regulatory groups to integrate biomarker strategies into clinical and regulatory plans
Job Requirements:
- Ph.D. in Genetics, Molecular Biology or a related field with a minimum of 4 years of additional research experience; Industry experience is desirable.
- Strong background in oncology/cancer research, with thorough understanding of signaling pathways implicated in disease and the mechanism of action of targeted therapies.
- Experience working with small molecule kinase inhibitors.
- Experience using a broad range of technologies to define biomarkers; including immunohistochemical, proteomic and, especially, genomic approaches.
- A very high level of motivation and a proven record of accomplishment (e.g. a strong publication record in top-tier journals).
- The ability to work effectively as part of a team.
- Outstanding written and oral communication skills.
